Expanding the Target Landscape by Drugging the Undruggable (R21 Clinical Trial Not Allowed)
Department of Health and Human Services
The purpose of this Notice of Funding Opportunity (NOFO) is to solicit applications for exploratory and early-stage projects that focus on undruggable target classes within intractable human disease. Applicants will identify a human disease relevant undruggable target class and develop a method or agent that is selective for one or more targets within that target class. This NOFO is intended to jumpstart research that demonstrates innovative strategies to modulate targets that cannot be addressed by established therapeutic types, furthering the development of methods and/or agents selective for undruggable target classes.
Funding
Award size
Not specified
Type
Grant
Dates
Deadline
Later
Posted
06/17/2025
Closes
2028-02-17
Eligibility
Eligibility
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher educationNative American tribal organizations (other than Federally recognized tribal governments)Private institutions of higher educationFor profit organizations other than small businessesCity or township governmentsPublic and State controlled institutions of higher educationState governmentsSmall businessesOthers (see text field entitled "Additional Information on Eligibility" for clarification)Public housing authorities/Indian housing authoritiesCounty governmentsSpecial district governmentsIndependent school districtsNative American tribal governments (Federally recognized)Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Program
Funding area
Health - HL
Opportunity #
PAR-25-442
Source
Status
Open
Market
Government
Level
Federal
Source
Grants.gov