HEAL Initiative: Non-addictive Analgesic Therapeutics Development [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Optional)
Department of Health and Human Services
The purpose of this Notice of Funding Opportunity (NOFO) is to support the preclinical optimization and development of safe, effective, and non-addictive small molecule and biologic therapeutics for the treatment of pain. The goal of the program is to accelerate the advancement of promising early-stage therapeutic candidates and facilitate their readiness for Phase II clinical trials. Applicants must have a promising small molecule or biologic lead candidate for optimization, a strong biological rationale for the proposed approach, and established assays to guide the optimization process. The scope of the program includes lead optimization, early-stage development activities, IND-enabling st
Funding
Award size
Not specified
Type
Cooperative Agreement
Dates
Deadline
Later
Posted
06/16/2026
Closes
2029-02-20
Eligibility
Eligibility
Private institutions of higher educationIndependent school districtsNonprofits having a 501(c)(3) status with the IRS, other than institutions of higher educationPublic and State controlled institutions of higher educationNonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher educationFor profit organizations other than small businessesSmall businessesOthers (see text field entitled "Additional Information on Eligibility" for clarification)County governmentsSpecial district governmentsCity or township governmentsNative American tribal governments (Federally recognized)Public housing authorities/Indian housing authoritiesNative American tribal organizations (other than Federally recognized tribal governments)State governments
Program
Funding area
Health - HL
Opportunity #
RFA-NS-27-007
Source
Status
Open
Market
Government
Level
Federal
Source
Grants.gov